From the work of my Master’s Thesis, I’ve taken a first step in the world of scientific publishing with the publication of my first paper: “On the Impact of Residual Strains in the Stress Analysis of Patient-Specific Atherosclerotic Carotid Vessels: Predictions Based on the Homogenous Stress Hypothesis”

Read the paper on Annals of Biomedical Engineering

On the Impact of Residual Strains in the Stress Analysis of Patient-Specific Atherosclerotic Carotid Vessels

Detecting carotid atherosclerotic lesions prone to plaque rupture, leading to cerebral embolism and stroke, is crucial clinically. Fibrous plaque cap stress is a known risk factor, but residual strains, among other factors, are overlooked in stress predictions.

We propose a Growth and Remodeling (G&R) framework, using multiplicative kinematics, to predict residual strains and assess their impact on plaque stress. Carotid morphology from four patients was reconstructed from Computed Tomography-Angiography (CT-A) images, with tissue properties assigned using AI image segmentation.

Incorporating residual strains reduced maximum wall stress and altered stress distribution across the atherosclerotic wall compared to purely elastic analysis. Despite homogenizing tissue stresses, the fibrous plaque cap may still face high stress zones. This highlights the importance of considering residual strains in biomechanical studies for a comprehensive assessment of fibrous plaque cap stress.

paper: https://link.springer.com/article/10.1007/s10439-024-03458-4

Biomechanics

Biomechanics, particularly in the context of cardiovascular disease, involves the study of how mechanical forces influence the structure and function of the cardiovascular system. This interdisciplinary field combines principles from engineering, physics, biology, and medicine to understand the biomechanical aspects of various cardiovascular conditions such as atherosclerosis, aneurysms, and heart valve diseases.

Computational modeling plays a crucial role in biomechanics by utilizing mathematical algorithms and computer simulations to analyze the complex interactions between blood flow, vessel walls, and surrounding tissues. Then, these models can provide insights into the development and progression of cardiovascular diseases, as well as aid in the design and optimization of medical devices and treatment strategies. For example, computational fluid dynamics (CFD) models are used to predict the hemodynamic forces acting on arterial walls. Similarly, finite element analysis (FEA) is employed to assess the mechanical integrity of heart valves and stents under different loading conditions.

Overall, biomechanics with computational modeling offers a powerful toolset for investigating the biomechanical factors contributing to cardiovascular disease pathogenesis, guiding the development of novel diagnostic techniques, therapeutic interventions, and patient-specific treatment plans aimed at improving cardiovascular health and patient outcomes.

Peer review publishing

Peer review publishing is a critical process in academic research where scholarly work is evaluated by independent experts in the field before publication. In solid mechanics and medical engineering, this rigorous scrutiny ensures the quality and credibility of research. By subjecting research to peer review, the fields of solid mechanics and medical engineering uphold rigorous standards of scientific integrity, fostering trust among researchers, practitioners, and the broader scientific community.

Open access

Moreover, open-access publication makes scholarly research freely accessible online to anyone without financial or legal barriers. Authors retain copyright, allowing widespread dissemination and increased visibility for their work. This model promotes greater collaboration, transparency, and innovation by democratizing access to knowledge across disciplines and geographic regions.