Wolfram Mathematica Masterclass

I just finished the “Wolfram Mathematica Masterclass: from Beginner to Expert” course held on the Udemy online platform by Dr. Börge Göbel. The course allowed me to refine the already established Skills within the Wolfram Mathematica environment and to touch further practical projects. Mathematica Wolfram Mathematica is a very powerful tool. It allows, with a very compact language, to solve Read more…

Microrheometer and viscoelastic properties of cells

The characterization of the mechanical properties of the cell is of great importance for estimating its biological state and physiology. Among the different measurement techniques, through the microrheometer it is possible to characterize the viscoelastic properties. In this report we consider a measurement experiment of a paramagnetic bead microrheometer and the fitting of experimental data to analyze the behavior of Read more…

Impedance cytometer and circuit equivalent

The equivalent circuit model for a parallel electrode impedance cytometer is analyzed together with Maxwell’s theory of homogenization of mixtures. It deals with both single shell and double shell cell modeling. The results show that even small errors in parameter estimation lead to variations in model predictions. Furthermore, the possibility of differentiating different biological states at different analysis frequencies is Read more…

Pseudo-rigid model for a compliant mechanism

Analysis of a compliant mechanism using Howell’s pseudo-rigid model and comparison with non-linear FEM analysis. The following article is an extract from a project carried out for the course of Advanced Techniques for the design of Prosthetic Devices. Held for Medical Engineering at the University of Rome Tor Vergata . Authors: Mastrofini Alessandro & Muscedere Erica Flexure hinges Some apparently rigid mechanisms allow Read more…

Diffusion and FEA for drug-eluting spheres

Mathematical modeling of diffusion mechanisms for drug delivery can be very useful for accelerating product development and for better understanding the mechanisms that control drug delivery from advanced delivery systems. The integration of Comsol’s numerical environment with programming in Matlab allows the development of customized and easily integrated solution models. These models easily allow diffusion analysis for drug-releasing systems with Read more…

Microsoft Excel Course: from Basic to Advanced Level

I completed the “Microsoft Excel: From Basic to Advanced” course held on the Udemy online platform. The course allowed me to refine some skills previously acquired in Excel, to acquire the methodology for implementing well-known mathematical operators in Excel and to improve in the use of the application in general. Spreadsheet A spreadsheet is productivity software that allows you to Read more…

Topological optimization for prototyping

Topological optimization analysis aimed at minimizing the mass of a hook fixed some design parameters, such as geometric constraints and load conditions. The following article is an extract from a project carried out for the course of Advanced Techniques for the design of Prosthetic Devices. Held for Medical Engineering at the University of Rome Tor Vergata . Authors: Mastrofini Alessandro & Muscedere Erica Read more…

Glucose minimal model and IVGTT test

Glucose is essential for human life and its concentration in the blood is strictly regulated. Alterations in blood glucose are a sign of numerous diseases and several clinical tests are used for diagnosis. The IVGTT test is a clinical exam that analyzes two important parameters such as the efficacy of glucose and insulin sensitivity. Using a mathematical model, such as Read more…

Physiological reflexes and control systems

Physiological reflexes are the basis of the organism’s survival. These reflexes allow, in a completely involuntary way, to maintain homeostasis. Variations in environmental variables or the appearance of a new signal induce a reflex response from the integration centers, aimed at restoring balance or avoiding dangerous situations. In the following report, the typical techniques of automatic controls are applied to Read more…

GrabCAD profile opening

Opening the profile GrabCAD sharing the models mentioned in the various articles. To view the profile: Alessandro Mastrofini GrabCAD CAD modeling CAD models are structures designed using computer and computer graphics. The acronym indicates computer-aided-design systems that aim to create 3D models of the product. If a 3D model is created, it can be used for calculations such as static, Read more…

Parametric optimization in prosthetic design

Parametric optimization analysis on a hip prosthesis stem subject to two load scenarios aimed at minimizing its mass while maintaining the stress state below the design limits. The following article is an extract from a project carried out for the course of Advanced Techniques for the design of Prosthetic Devices. Held for Medical Engineering at the University of Rome Tor Read more…