Physiological systems modeling, simulation, and control is a research area integrating science and engineering and contributes to a continuous refinement of knowledge on how the body works
I finished my experience in the Summer School entitled “Computational Tissue Biomechanics: From in-vitro experiment to computational analysis“. The course introduces and applies state-of-the-art tools in the continuum mechanical analysis of biological tissues. It is designed for master students and PhD students having a decent background in mechanical engineering and Read more…
Cardiovascular diseases are the cause of numerous deaths. Among these, abdominal aortic aneurysms are very dangerous for which adequate techniques for diagnosis and prevention have not yet been developed. The implementation of numerical analyzes can help analyze the influence of geometric and material parameters on the risk of aneurysm rupture. Read more…
The characterization of the mechanical properties of the cell is of great importance for estimating its biological state and physiology. Among the different measurement techniques, through the microrheometer it is possible to characterize the viscoelastic properties. In this report we consider a measurement experiment of a paramagnetic bead microrheometer and Read more…
The equivalent circuit model for a parallel electrode impedance cytometer is analyzed together with Maxwell’s theory of homogenization of mixtures. It deals with both single shell and double shell cell modeling. The results show that even small errors in parameter estimation lead to variations in model predictions. Furthermore, the possibility Read more…
Mathematical modeling of diffusion mechanisms for drug delivery can be very useful for accelerating product development and for better understanding the mechanisms that control drug delivery from advanced delivery systems. The integration of Comsol’s numerical environment with programming in Matlab allows the development of customized and easily integrated solution models. Read more…
Glucose is essential for human life and its concentration in the blood is strictly regulated. Alterations in blood glucose are a sign of numerous diseases and several clinical tests are used for diagnosis. The IVGTT test is a clinical exam that analyzes two important parameters such as the efficacy of Read more…
Physiological reflexes are the basis of the organism’s survival. These reflexes allow, in a completely involuntary way, to maintain homeostasis. Variations in environmental variables or the appearance of a new signal induce a reflex response from the integration centers, aimed at restoring balance or avoiding dangerous situations. In the following Read more…
In impedance cytometry, various design and post processing techniques have been developed to improve measurement accuracy. One of the parameters that most afflicts cytometry measurements is the dependence of the signal on the position of the cell within the channel so that identical cells, passing in different positions, give rise Read more…
FEM analysis aimed at characterizing the mechanical behavior of the stem of a hip prosthesis inserted inside a femur. The following article is an extract from a project carried out for the course of Advanced Techniques for the Design of Prosthetic Devices. Held for Medical Engineering at the University of Rome Read more…
A linear model of lung mechanics is analyzed in the following report. The model corresponds to an RLC circuit with unknown parameters. Parametric identification allows to trace the system governance coefficients once a mathematical model has been estimated. Different approaches allow to minimize the difference between the estimated parameters and Read more…
Pulmonary ventilation is a critical operation both during surgery and for assisted or replacement ventilation of the patient. This report proposes the analysis of a lung mechanics model through an electrical analogy with an equivalent circuit consisting of resistors and capacitors. This electrical-mechanical analogy makes it possible to analyze how Read more…
The following report introduces various simulation campaigns aimed at homogenizing trabecular bone tissue.Background, analyzing the structure of the trabecular bone it is evident how the shape of the pores and the trabecular structure influence the stiffness and the structural response. It is analyzed how the variation of the pore geometry Read more…